Associate/Research Scientist, Biochemistry at Kleo Pharmaceuticals Inc.
New Haven*, CT, US

We are seeking a highly motivated scientist and team player to join our Biochemistry group and make major scientific contributions to advance our product pipeline. This individual will assist in early stage discovery projects in immuno-oncology and develop the technologies and protocols to achieve important milestones in program development.

This position will require experience with the production, purification, and pre-clinical development of biologics, including monoclonal antibodies and/or their derivatives. Expertise with antibody drug conjugation (ADC) and their analysis. This candidate will possess a current knowledge in developing Antibody conjugation methods, product purification, and analysis of drug-to-antibody ratio (DAR).

Accordingly, our ideal candidate will have proficiency in a wide range of laboratory techniques–especially pertaining to the characterization of bi-specific antibodies, antibody-derived fragments (Fab, scFv, etc), and/or monoclonal antibodies. Experience with cutting-edge technologies in ADC field is a plus.

This position requires at least 2 years of relevant industry or academic experience, ideally with preparation of ADC and analytical methods development, and strong scientific research background. Our hire will work as part of a multidisciplinary team in a fast-paced environment. If you are passionate about advancing healthcare and this position is in agreement with your career goals, we would love to hear from you.

Candidate Qualifications 

  • B.S. with 8+, M.S. with 6+, or PhD with 2+ years of experience working with ADC in pharmaceutical or academic lab

  • Hands on experience with various methods of ADC preparation, purification and analysis

  • Expertise with binding assays (i.e. ELISA, MST, FRET, AlphaScreen, flow cytometry, etc.) using recombinant and cellular surface proteins is a plus

  • The ideal candidate would have strong knowledge about ADC, biochemistry of antibody derivatives (i.e. BITE, DART, TandAb, Fab, scFv, etc.) and immuno-oncology targets

  • Ability to work as part of a multidisciplinary team and multitask between different projects.

  • Experience with standard data analysis software (e.g. Microsoft Excel, Prism, etc.)